San Francisco’s startup scene is heating up—and these 20 companies are leading the charge. With fast growth, strong investor interest, and funding rounds gaining momentum, they’re on a clear path toward the $100M milestone. Operating across AI, biotech, fintech, and enterprise tech, they’re building the kind of scalable innovation that attracts serious capital
20 Rising Stars on the Brink of Breakout Success
With accelerating traction, bold visions, and market-ready products, these startups are poised to join the next tier of industry leaders.
Let’s meet the San Francisco companies turning momentum into millions.
| Company | Founded | Industry | Employees | Last Amount | Last Funding | Total Funding |
|---|---|---|---|---|---|---|
| Canary Technologies | 2017 | Enterprise Software, Hospitality | 251–500 | $50M | Jun 12, 2024 | $97M |
| Indapta Therapeutics | 2017 | Biopharma, Biotechnology | 1–10 | $22.5M | Dec 17, 2024 | $77M |
| Transcend | 2017 | Cloud Infrastructure, Compliance | 11–50 | $40M | May 28, 2024 | $68.95M |
| Scribe | 2019 | Internet, Productivity Tools | 51–100 | $25M | Feb 15, 2024 | $55M |
| Vividly | 2017 | Consumer Goods, Information Technology | 51–100 | $30M | Jan 14, 2025 | $62.71M |
| Klarity | 2017 | Accounting, AI | 11–50 | $70M | Jun 24, 2024 | $90.38M |
| Motion | 2019 | Analytics, AI | 11–50 | $36.49M | Jun 13, 2024 | $63.57M |
| Sofar Ocean | 2016 | Big Data, Information Services | 101–250 | $18.25M | Dec 9, 2024 | $69.95M |
| Two Chairs | 2017 | Health Care, Mental Health | 501–1,000 | $72M | Apr 16, 2024 | $100M |
| Mantle | 2015 | 3D Printing, Industrial Manufacturing | 51–100 | $20M | Jul 10, 2024 | $58M |
| Peregrine Technologies | 2018 | Analytics, Information Technology | 101–250 | $30M | May 1, 2024 | $60.12M |
| Constructor | 2015 | AI, Machine Learning | 101–250 | $25M | Jun 17, 2024 | $86.1M |
| KarmaCheck | 2019 | AI, Compliance | 101–250 | $45M | Jun 27, 2024 | $64.2M |
| Polly | 2019 | Big Data, Computer | 101–250 | $25M | Sep 10, 2024 | $77M |
| unspun | 2017 | 3D Technology, Apparel | 11–50 | $32M | Jul 29, 2024 | $58.45M |
| Openwater | 2016 | AI, Manufacturing | 11–50 | $54M | Aug 22, 2024 | $76M |
| Bigeye | 2019 | Analytics, AI | 11–50 | $5M | Oct 9, 2024 | $73.5M |
| GALY | 2019 | Biotechnology, Chemical | 51–100 | $33M | Sep 3, 2024 | $65.92M |
| CodePath | 2015 | Communities, Education | 11–50 | $50M | Sep 18, 2024 | $73.1M |
| WeaveGrid | 2018 | Automotive, Electric Vehicle | 51–100 | $28M | Dec 10, 2024 | $78M |
1. Canary Technologies
- Founded: 2017
- Location: San Francisco, California
- Industry: Enterprise Software, Hospitality
- Number of Employees: 251–500
- Last Funding Amount: $50M (Latest Round: Jun 12, 2024)
- Total Funding Amount: $97M
Canary Technologies provides enterprise-grade software solutions for the hospitality industry, helping hotels digitize operations and enhance guest experiences. Its platform offers tools for contactless check-in, upselling, payment security, and guest messaging. Trusted by leading hotel brands, Canary empowers properties to streamline workflows, increase revenue, and modernize the guest journey.
2. Indapta Therapeutics
- Founded: 2017
- Location: San Francisco, California
- Industry: Biopharma, Biotechnology
- Number of Employees: 1–10
- Last Funding Amount: $22.5M (Latest Round: Dec 17, 2024)
- Total Funding Amount: $77M
Indapta Therapeutics is a biotechnology company pioneering cell-based immunotherapies for cancer treatment. Its platform harnesses a unique subset of natural killer (NK) cells—called G-NK cells—to deliver potent, targeted anti-tumor activity with minimal toxicity. With a focus on scalable manufacturing and off-the-shelf therapies, Indapta is advancing a new generation of cancer immunotherapy.
3. Transcend
- Founded: 2017
- Location: San Francisco, California
- Industry: Cloud Infrastructure, Compliance
- Number of Employees: 11–50
- Last Funding Amount: $40M (Latest Round: May 28, 2024)
- Total Funding Amount: $68.95M
Transcend provides data privacy and compliance infrastructure for modern enterprises, enabling automated control over personal data across internal systems and third-party tools. Its platform supports global privacy regulations like GDPR and CCPA, allowing companies to fulfill data subject requests, manage consent, and enforce data governance at scale. With security-first design and seamless integrations, Transcend ensures privacy compliance without slowing down innovation.
4. Scribe
- Founded: 2019
- Location: San Francisco, California
- Industry: Internet, Productivity Tools
- Number of Employees: 51–100
- Last Funding Amount: $25M (Latest Round: Feb 15, 2024)
- Total Funding Amount: $55M
Scribe offers a productivity platform that automatically generates step-by-step guides by capturing workflows in real time. Designed for teams and enterprises, its tool streamlines knowledge sharing, onboarding, and documentation. With intuitive browser and desktop integrations, Scribe helps users turn routine tasks into reusable, visual SOPs—saving time and boosting organizational efficiency.
5. Vividly
- Founded: 2017
- Location: San Francisco, California
- Industry: Consumer Goods, Information Technology
- Number of Employees: 51–100
- Last Funding Amount: $30M (Latest Round: Jan 14, 2025)
- Total Funding Amount: $62.71M
Vividly provides a trade promotion management (TPM) platform tailored for consumer goods brands, helping teams plan, execute, and analyze promotional spend in real time. By replacing spreadsheets with data-driven tools, Vividly improves forecasting accuracy, boosts ROI, and enhances cross-functional collaboration. The platform empowers brands to manage trade budgets more strategically and transparently.
6. Klarity
- Founded: June 5, 2017
- Location: San Francisco, California
- Industry: Accounting, Artificial Intelligence (AI)
- Number of Employees: 11–50
- Last Funding Amount: $70M (Latest Round: Jun 24, 2024)
- Total Funding Amount: $90.38M
Klarity uses AI to automate document review and data extraction for finance and accounting teams. Its platform processes contracts, invoices, and other business documents with high accuracy, reducing manual workload and compliance risk. By integrating seamlessly with existing financial systems, Klarity accelerates workflows and ensures consistent, audit-ready results across enterprise operations.
7. Motion
- Founded: March 1, 2019
- Location: San Francisco, California
- Industry: Analytics, Artificial Intelligence (AI)
- Number of Employees: 11–50
- Last Funding Amount: $36.49M (Latest Round: Jun 13, 2024)
- Total Funding Amount: $63.57M
Motion leverages AI to help professionals and teams optimize their time with an intelligent calendar and task management platform. By automatically scheduling meetings, prioritizing tasks, and adapting plans in real time, Motion eliminates the friction of daily planning. Designed to boost productivity and reduce burnout, Motion empowers users to focus on what matters most.
8. Sofar Ocean
- Founded: 2016
- Location: San Francisco, California
- Industry: Big Data, Information Services
- Number of Employees: 101–250
- Last Funding Amount: $18.25M (Latest Round: Dec 9, 2024)
- Total Funding Amount: $69.95M
Sofar Ocean operates a global ocean intelligence platform powered by real-time data from its proprietary network of ocean sensors. It delivers insights that help maritime and logistics companies optimize shipping routes, reduce fuel consumption, and lower emissions. Combining big data with predictive analytics, Sofar Ocean is transforming how industries interact with and protect the world’s oceans.
9. Two Chairs
- Founded: 2017
- Location: San Francisco, California
- Industry: Health Care, Mental Health
- Number of Employees: 501–1,000
- Last Funding Amount: $72M (Latest Round: Apr 16, 2024)
- Total Funding Amount: $100M
Two Chairs is a mental health care provider offering personalized therapy through a hybrid model of in-person and virtual care. By using a data-driven matching process, it connects clients with therapists best suited to their unique needs and preferences. Focused on clinical excellence and accessibility, Two Chairs is redefining the standard of care in mental health.
10. Mantle
- Founded: 2015
- Location: San Francisco, California
- Industry: 3D Printing, Industrial Manufacturing
- Number of Employees: 51–100
- Last Funding Amount: $20M (Latest Round: Jul 10, 2024)
- Total Funding Amount: $58M
Mantle specializes in advanced 3D printing solutions for industrial manufacturing, offering scalable metal additive manufacturing technology. Its platform enables rapid prototyping and production of complex parts with precision and durability. By combining innovative hardware with proprietary software, Mantle is driving the next wave of manufacturing efficiency and customization.
11. Peregrine Technologies
- Founded: 2018
- Location: San Francisco, California
- Industry: Analytics, Information Technology
- Number of Employees: 101–250
- Last Funding Amount: $30M (Latest Round: May 1, 2024)
- Total Funding Amount: $60.12M
Peregrine Technologies delivers advanced analytics solutions that help enterprises harness data for strategic decision-making. Its platform integrates disparate data sources to provide real-time insights, predictive modeling, and operational intelligence. Focused on scalability and user experience, Peregrine empowers organizations to unlock value from complex data ecosystems.
12. Constructor
- Founded: 2015
- Location: San Francisco, California
- Industry: Artificial Intelligence (AI), Machine Learning
- Number of Employees: 101–250
- Last Funding Amount: $25M (Latest Round: Jun 17, 2024)
- Total Funding Amount: $86.1M
Constructor leverages AI and machine learning to power search and discovery for e-commerce platforms. Its technology improves product relevance, personalization, and conversion rates by understanding user intent and behavior. Built for scalability and performance, Constructor enables retailers to deliver fast, accurate, and engaging shopping experiences.
13. KarmaCheck
- Founded: September 2019
- Location: San Francisco, California
- Industry: Artificial Intelligence (AI), Compliance
- Number of Employees: 101–250
- Last Funding Amount: $45M (Latest Round: Jun 27, 2024)
- Total Funding Amount: $64.2M
KarmaCheck uses AI to streamline background checks and credential verification, delivering faster, more accurate hiring decisions. Its platform automates identity, education, license, and employment verification with real-time data and intuitive workflows. Designed for speed and compliance, KarmaCheck empowers employers to build trusted teams while improving the candidate experience.
14. Polly
- Founded: 2019
- Location: San Francisco, California
- Industry: Big Data, Computer
- Number of Employees: 101–250
- Last Funding Amount: $25M (Latest Round: Sep 10, 2024)
- Total Funding Amount: $77M
Polly delivers AI-powered analytics and data infrastructure to support faster, smarter decision-making across industries. Its platform turns massive, complex datasets into actionable insights through real-time processing, customizable dashboards, and collaborative tools. With a focus on usability and scale, Polly empowers teams to harness big data without needing a data science background.
15. unspun
- Founded: 2017
- Location: San Francisco, California
- Industry: 3D Technology, Apparel
- Number of Employees: 11–50
- Last Funding Amount: $32M (Latest Round: Jul 29, 2024)
- Total Funding Amount: $58.45M
unspun is a fashion technology company leveraging 3D technology and robotics to produce custom-fit apparel with minimal waste. Its platform combines body scanning, digital design, and automated manufacturing to deliver on-demand, sustainable clothing. By eliminating inventory and overproduction, unspun is redefining how clothes are made—and reducing fashion’s environmental footprint.
16. Openwater
- Founded: 2016
- Location: San Francisco, California
- Industry: Artificial Intelligence (AI), Manufacturing
- Number of Employees: 11–50
- Last Funding Amount: $54M (Latest Round: Aug 22, 2024)
- Total Funding Amount: $76M
Openwater is developing cutting-edge imaging and manufacturing technologies powered by AI to revolutionize medical diagnostics and industrial applications. Using novel optics and computational imaging, the company aims to replace bulky, expensive equipment with compact, high-resolution systems. With applications ranging from brain scanning to defect detection, Openwater is pushing the boundaries of what’s possible in precision manufacturing and healthcare.
17. Bigeye
- Founded: 2019
- Location: San Francisco, California
- Industry: Analytics, Artificial Intelligence (AI)
- Number of Employees: 11–50
- Last Funding Amount: $5M (Latest Round: Oct 9, 2024)
- Total Funding Amount: $73.5M
Bigeye offers a data observability platform that uses AI to monitor and ensure the reliability of enterprise data pipelines. Its tools detect anomalies, track data quality metrics, and alert teams to issues before they impact operations. With deep integration across modern data stacks, Bigeye empowers organizations to maintain trust in their data and scale analytics with confidence.
18. GALY
- Founded: 2019
- Location: San Francisco, California
- Industry: Biotechnology, Chemical
- Number of Employees: 51–100
- Last Funding Amount: $33M (Latest Round: Sep 3, 2024)
- Total Funding Amount: $65.92M
GALY is a biotechnology company pioneering lab-grown cotton through cellular agriculture, aiming to revolutionize textile production. Its process cultivates cotton from cells rather than fields, drastically reducing water usage, land dependency, and environmental impact. With a focus on sustainability and scalability, GALY is reimagining the future of fashion and agriculture.
19. CodePath
- Founded: January 20, 2015
- Location: San Francisco, California
- Industry: Communities, Education
- Number of Employees: 11–50
- Last Funding Amount: $50M (Latest Round: Sep 18, 2024)
- Total Funding Amount: $73.1M
CodePath is a nonprofit organization focused on expanding access to tech education for underrepresented students. It partners with universities and employers to deliver industry-relevant courses, mentorship, and career support at scale. By bridging the gap between academia and the tech workforce, CodePath empowers a new generation of diverse software engineers.
20. WeaveGrid
- Founded: 2018
- Location: San Francisco, California
- Industry: Automotive, Electric Vehicle
- Number of Employees: 51–100
- Last Funding Amount: $28M (Latest Round: Dec 10, 2024)
- Total Funding Amount: $78M
WeaveGrid develops software that connects electric vehicles (EVs) with the power grid to optimize charging and support grid reliability. Its platform uses data-driven algorithms to align EV charging with renewable energy supply, reduce grid strain, and lower costs for utilities and drivers. By bridging transportation and energy, WeaveGrid accelerates the clean energy transition.
Conclusion
These 20 San Francisco startups are catching fire—with strong momentum, standout teams, and funding rounds that signal $100M is within reach. Positioned across sectors like AI, fintech, climate tech, and health, they’re scaling fast and solving complex problems with next-gen solutions. As they move toward growth-stage funding, they’re poised to become the city’s next breakout success stories.
FAQs
Q1. How close are they to reaching $100M in total funding?
A. Many are approaching the milestone, with recent rounds putting them in the $30M–$80M range and signaling readiness for larger growth investments.
Q2. What are their primary growth strategies?
A. They’re focused on product expansion, strategic hiring, international market entry, and deepening enterprise partnerships.
Q3. What sets these companies apart from earlier-stage startups?
A. They’ve moved beyond MVPs and early pilots, demonstrating scale, operational maturity, and the ability to serve larger markets.